Citizens Volunteer Hospital - corner of Broad St. and Washington Ave. / drawn & lith. by James Queen, Philada.

Clara Barton, (December 25, 1821 – April 12, 1912), founder the American Red Cross, declared that the war put the American woman “at least fifty years in advance of the normal position which continued peace would have assigned her.” Clara Barton was born in North Oxford. When Clara was 10, she assigned herself the task of nursing her brother David back to health after he fell from the roof of a barn. Clara learned how to distribute the prescribed medication to her brother, as well as how to place leeches on his body to bleed him (a standard treatment at this time). She continued to care for David long after doctors had given until he made a full recovery. She was a teacher for 12 years at schools in Canada, West Georgia and at open a free school in Bordentown, NJ which was the first ever free school in New Jersey. She was also a patent clerk in Washington D.C., in the US Patent Office. She was the first woman in government office who had received a salary equal to a man's salary. She became a hospital nurse during the American Civil War. Nursing education was not formalized at that time and Clara did not attend nursing school and provided self-taught nursing care. On April 19, 1861, the Baltimore Riot resulted in the first bloodshed of the American Civil War. Victims were transported to Washington D.C. where she lived at the time. Barton went to the railroad station when the victims arrived and nursed 40 men providing crucial assistance to wounded.

The Americana collection of Marian Sadtler Carson (1905-2004) spans the years 1656-1995 with the bulk of the material dating from 1700 to 1876. The collection includes more than 10,000 historical letters and manuscripts, broadsides, photographs, prints and drawings, books and pamphlets, maps, and printed ephemera from the colonial era through the 1876 centennial of the United States. It is believed to be the most extensive existing private collection of early Americana. The collection includes such important and diverse historical treasures as unpublished papers of Revolutionary War figures and the Continental Congress; letters of several American presidents, including Thomas Jefferson; a manuscript account of the departure of the first Pony Express rider from St. Joseph, Mo.; and what may be the earliest photograph of a human face. Many of the rare books and pamphlets in the collection pertain to the early Congresses of the United States, augmenting the Library's unparalleled collection of political pamphlets and imprints. The Carson Collection adds to the Library's holdings the first presidential campaign biography, John Beckley's Address to the people of the United States with an Epitome and vindication of the Public Life and Character of Thomas Jefferson, published in Philadelphia in 1800. The book was written to counter numerous attacks against Jefferson's character, which appeared in newspapers and pamphlets during the bitter election campaign. The Rare Book and Special Collections Division shares custodial responsibility for the collection with the Library's Geography and Map Division, Music Division, Prints and Photographs Division, and the Manuscript Division.

Alois Senefelder, the inventor of lithography, introduced the subject of colored lithography in 1818. Printers in other countries, such as France and England, were also started producing color prints. The first American chromolithograph—a portrait of Reverend F. W. P. Greenwood—was created by William Sharp in 1840. Chromolithographs became so popular in American culture that the era has been labeled as "chromo civilization". During the Victorian times, chromolithographs populated children's and fine arts publications, as well as advertising art, in trade cards, labels, and posters. They were also used for advertisements, popular prints, and medical or scientific books.